Mast cells are a type of white blood cell that play a crucial role in the immune system, particularly in allergic reactions and inflammation. They are found in tissues throughout the body and are involved in defending against pathogens and regulating immune responses. Mast cells are heavily involved in allergic reactions. They release histamine and other mediators when triggered by allergens, causing the symptoms of allergies. They are activated by various stimuli, including allergens (through IgE antibodies), certain drugs, and even physical stimuli like heat or pressure.
Mast Cell Activation Syndromes (MCAS) & Carpa: A condition marked by repeated episodes of severe, allergy-like symptoms (e.g., hives, swelling, difficulty breathing, abdominal pain) without a clear trigger.