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Diagnosis and management of disorders like Carpa often require consultation with specialists, including immunologists, hematologists, gastroenterologists, and allergists. The following tests help diagnose and deepen the understanding of Carpa.

Timing of tests:
For some mediators, like tryptase, the timing of the test in relation to a mast cell activation episode is crucial
  • Tryptase, to evaluate mast cell activation
  • Biopsies:
  • Imaging Tests: Imaging tests like CT scans, ultrasounds, and bone scans may be used to assess organ involvement
  • Allergy Skin Tests
  • Genetic Testing:
  • Genetic testing for KIT mutations can be used as a diagnostic marker and a target for therapy.
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Anaphylatoxins
are small peptides, primarily C3a, C4a, and C5a, generated during the activation of the complement system, a part of the immune system. They are pro-inflammatory mediators that play a crucial role in innate immunity by initiating and regulating inflammatory responses. hese peptides cause effects like smooth muscle contraction, increased vascular permeability, and histamine release from mast cells, ultimately contributing to the inflammatory response
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Mast cells
are a type of white blood cell that play a crucial role in the immune system, particularly in allergic reactions and inflammation. They are found in tissues throughout the body and are involved in defending against pathogens and regulating immune responses. Mast cells are heavily involved in allergic reactions. They release histamine and other mediators when triggered by allergens, causing the symptoms of allergies. They are activated by various stimuli, including allergens (through IgE antibodies), certain drugs, and even physical stimuli like heat or pressure. 

Mast Cell Activation Syndromes (MCAS) & Carpa: A condition marked by repeated episodes of severe, allergy-like symptoms (e.g., hives, swelling, difficulty breathing, abdominal pain) without a clear trigger. 


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